The Pediatric Intensive Care Unit (PICU) at C.S. Mott Children's Hospital at the University of Michigan houses 22 beds for children with medical or surgical illnesses requiring the highest level of intensive care and monitoring. The PICU provides 24-hour care by a multidisciplinary care team of nurses, respiratory therapists, pharmacists, nutritionists -- all led by board-certified pediatric intensivists, critical care fellows, and pediatric residents. Our PICU enjoys an international reputation for excellence in the care of children with respiratory failure, especially those who require artificial organ support. Subjects of ongoing research in our PICU include the intensive care of respiratory failure, sepsis, multiple organ failure, asthma, increased intracranial pressure, bereavement, and teamwork. Nationally recognized programs in artificial organ support with extracorporeal membrane oxygenation (ECMO) and continuous hemodialysis (CRRT) are unique to this critical care unit. In additon, the faculty in the Division of Pediatric Critical Care Medicine lead some of the most cutting edge research to better understand the pathobiology of critical illness and develop novel therapeutic strategies and life-saving techonologies to better care for critically ill and injured children.